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SMILES: Cc1cnc(s1)C(O)C1CCCN(C1)c1ncnc2cc(ccc12)N1CCOCC1

InChI Key: InChIKey=UNRVITUMVUGDDZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 179344   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))		BDBM179344
PNG
(US9126952, 47)
Show SMILES Cc1cnc(s1)C(O)C1CCCN(C1)c1ncnc2cc(ccc12)N1CCOCC1
Show InChI InChI=1S/C22H27N5O2S/c1-15-12-23-22(30-15)20(28)16-3-2-6-27(13-16)21-18-5-4-17(11-19(18)24-14-25-21)26-7-9-29-10-8-26/h4-5,11-12,14,16,20,28H,2-3,6-10,13H2,1H3
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Similars
US Patent
n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...

US Patent US9126952 (2015)


BindingDB Entry DOI: 10.7270/Q2JH3JZ2
More data for this
Ligand-Target Pair