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SMILES: O[C@H](CN1[C@@H](CN(Cc2ccc(Cl)cc2)c2ccccc12)c1cccc(c1)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=YLONPNYVCUEEMT-XZOQPEGZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 179508   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cholesteryl ester transfer protein


(Homo sapiens (Human))		BDBM179508
PNG
(US9126976, 39)
Show SMILES O[C@H](CN1[C@@H](CN(Cc2ccc(Cl)cc2)c2ccccc12)c1cccc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C25H21ClF6N2O/c26-19-10-8-16(9-11-19)13-33-14-22(17-4-3-5-18(12-17)24(27,28)29)34(15-23(35)25(30,31)32)21-7-2-1-6-20(21)33/h1-12,22-23,35H,13-15H2/t22-,23+/m0/s1
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Similars
US Patent
n/an/a 548n/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
First, low density lipoprotein (LDL) (Meridian) was biotinylated by incubating LDL with biotin for 1 hour on ice, after which it was dialyzed to remo...

US Patent US9126976 (2015)


BindingDB Entry DOI: 10.7270/Q25B018M
More data for this
Ligand-Target Pair