BDBM179698 US9127001, 8e::US9598410, Compound 8e

SMILES: CS(=O)(=O)c1cccc(c1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N

InChI Key: InChIKey=HHFPRKUULCNJSE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 179698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM179698 (US9127001, 8e | US9598410, Compound 8e) Show SMILES CS(=O)(=O)c1cccc(c1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N Show InChI InChI=1S/C28H22F2N4O3S/c1-38(36,37)23-7-3-6-20(13-23)28(35)33-11-10-26-24(17-33)27(19-5-2-4-18(12-19)15-31)32-34(26)16-21-8-9-22(29)14-25(21)30/h2-9,12-14H,10-11,16-17H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
SANOFI US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...				US Patent US9598410 (2017) BindingDB Entry DOI: 10.7270/Q2377BRM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM179698 (US9127001, 8e | US9598410, Compound 8e) Show SMILES CS(=O)(=O)c1cccc(c1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N Show InChI InChI=1S/C28H22F2N4O3S/c1-38(36,37)23-7-3-6-20(13-23)28(35)33-11-10-26-24(17-33)27(19-5-2-4-18(12-19)15-31)32-34(26)16-21-8-9-22(29)14-25(21)30/h2-9,12-14H,10-11,16-17H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	25
Sanofi US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...				US Patent US9127001 (2015) BindingDB Entry DOI: 10.7270/Q2HM576Z
					More data for this Ligand-Target Pair