BDBM179726 US9127001, 12b::US9598410, Compound 12b

SMILES: CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(=O)N1CCOCC1)-c1ccc(F)cc1

InChI Key: InChIKey=LGGYNYOUXDCXCT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 179726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM179726 (US9127001, 12b | US9598410, Compound 12b) Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(=O)N1CCOCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H26F2N4O2/c1-17(18-2-6-20(26)7-3-18)31-23-10-11-30(25(32)29-12-14-33-15-13-29)16-22(23)24(28-31)19-4-8-21(27)9-5-19/h2-9,17H,10-16H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	511	n/a	n/a	n/a	n/a	n/a	n/a
SANOFI US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...				US Patent US9598410 (2017) BindingDB Entry DOI: 10.7270/Q2377BRM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM179726 (US9127001, 12b | US9598410, Compound 12b) Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(=O)N1CCOCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H26F2N4O2/c1-17(18-2-6-20(26)7-3-18)31-23-10-11-30(25(32)29-12-14-33-15-13-29)16-22(23)24(28-31)19-4-8-21(27)9-5-19/h2-9,17H,10-16H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	511	n/a	n/a	n/a	n/a	n/a	25
Sanofi US Patent					Assay Description Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...				US Patent US9127001 (2015) BindingDB Entry DOI: 10.7270/Q2HM576Z
					More data for this Ligand-Target Pair