null
SMILES: CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
InChI Key: InChIKey=BLJXRMKAAJLGJY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat)) | BDBM179978 (US9669035, B-15) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in... | US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM179978 (US9669035, B-15) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.8 | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf... | US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H | |||||||||||
More data for this Ligand-Target Pair |