BDBM180784 US8865745, 6

SMILES: COc1ccc(cc1OCC(F)(F)F)C1=NN(C2CCN(CC2)C(=O)CN2C(=O)CCC2=O)C(=O)C1(C)C

InChI Key: InChIKey=JAAFNIDHDGPHDM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM180784 (US8865745, 6) Show SMILES COc1ccc(cc1OCC(F)(F)F)C1=NN(C2CCN(CC2)C(=O)CN2C(=O)CCC2=O)C(=O)C1(C)C |t:15| Show InChI InChI=1S/C25H29F3N4O6/c1-24(2)22(15-4-5-17(37-3)18(12-15)38-14-25(26,27)28)29-32(23(24)36)16-8-10-30(11-9-16)21(35)13-31-19(33)6-7-20(31)34/h4-5,12,16H,6-11,13-14H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	7.4	37
Takeda GmbH US Patent					Assay Description PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...				US Patent US8865745 (2014) BindingDB Entry DOI: 10.7270/Q2XK8DBB
					More data for this Ligand-Target Pair