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SMILES: CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(F)c2[nH]ccc12

InChI Key: InChIKey=BLEFJHDCLNVQNS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 180862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM180862 (US9133180, 3) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(F)c2[nH]ccc12 Show InChI InChI=1S/C24H24FN5O2/c1-24(2)13-30(12-11-28-24)15-5-3-14(4-6-15)21-20(22(26)31)29-23(32-21)17-7-8-18(25)19-16(17)9-10-27-19/h3-10,27-28H,11-13H2,1-2H3,(H2,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.4	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [K633Q] (Homo sapiens (Human))	BDBM180862 (US9133180, 3) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(F)c2[nH]ccc12 Show InChI InChI=1S/C24H24FN5O2/c1-24(2)13-30(12-11-28-24)15-5-3-14(4-6-15)21-20(22(26)31)29-23(32-21)17-7-8-18(25)19-16(17)9-10-27-19/h3-10,27-28H,11-13H2,1-2H3,(H2,26,31)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.821	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM180862 (US9133180, 3) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(F)c2[nH]ccc12 Show InChI InChI=1S/C24H24FN5O2/c1-24(2)13-30(12-11-28-24)15-5-3-14(4-6-15)21-20(22(26)31)29-23(32-21)17-7-8-18(25)19-16(17)9-10-27-19/h3-10,27-28H,11-13H2,1-2H3,(H2,26,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.36	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair