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SMILES: Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(o1)-c1ccc(cc1)N1CCNC(C)(C)C1

InChI Key: InChIKey=OPWLMVVARKPWEA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 180866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM180866 (US9133180, 7) Show SMILES Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(o1)-c1ccc(cc1)N1CCNC(C)(C)C1 Show InChI InChI=1S/C25H26FN5O2/c1-14-12-18(26)20-17(8-9-28-20)19(14)24-30-21(23(27)32)22(33-24)15-4-6-16(7-5-15)31-11-10-29-25(2,3)13-31/h4-9,12,28-29H,10-11,13H2,1-3H3,(H2,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	42.5	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM180866 (US9133180, 7) Show SMILES Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(o1)-c1ccc(cc1)N1CCNC(C)(C)C1 Show InChI InChI=1S/C25H26FN5O2/c1-14-12-18(26)20-17(8-9-28-20)19(14)24-30-21(23(27)32)22(33-24)15-4-6-16(7-5-15)31-11-10-29-25(2,3)13-31/h4-9,12,28-29H,10-11,13H2,1-3H3,(H2,27,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM180866 (US9133180, 7) Show SMILES Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(o1)-c1ccc(cc1)N1CCNC(C)(C)C1 Show InChI InChI=1S/C25H26FN5O2/c1-14-12-18(26)20-17(8-9-28-20)19(14)24-30-21(23(27)32)22(33-24)15-4-6-16(7-5-15)31-11-10-29-25(2,3)13-31/h4-9,12,28-29H,10-11,13H2,1-3H3,(H2,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.93	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair