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SMILES: Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(o3)-c3ccc(cc3)N3CCNC(C)(C)C3)c12

InChI Key: InChIKey=AYVATFZLZLWIPA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 180867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM180867 (US9133180, 8) Show SMILES Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(o3)-c3ccc(cc3)N3CCNC(C)(C)C3)c12 Show InChI InChI=1S/C25H27N5O2/c1-15-13-27-19-6-4-5-18(20(15)19)24-29-21(23(26)31)22(32-24)16-7-9-17(10-8-16)30-12-11-28-25(2,3)14-30/h4-10,13,27-28H,11-12,14H2,1-3H3,(H2,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	271	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [K633Q] (Homo sapiens (Human))	BDBM180867 (US9133180, 8) Show SMILES Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(o3)-c3ccc(cc3)N3CCNC(C)(C)C3)c12 Show InChI InChI=1S/C25H27N5O2/c1-15-13-27-19-6-4-5-18(20(15)19)24-29-21(23(26)31)22(32-24)16-7-9-17(10-8-16)30-12-11-28-25(2,3)14-30/h4-10,13,27-28H,11-12,14H2,1-3H3,(H2,26,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM180867 (US9133180, 8) Show SMILES Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(o3)-c3ccc(cc3)N3CCNC(C)(C)C3)c12 Show InChI InChI=1S/C25H27N5O2/c1-15-13-27-19-6-4-5-18(20(15)19)24-29-21(23(26)31)22(32-24)16-7-9-17(10-8-16)30-12-11-28-25(2,3)14-30/h4-10,13,27-28H,11-12,14H2,1-3H3,(H2,26,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair