BDBM180871 US9133180, 12

SMILES: CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(c2[nH]ccc12)C(F)(F)F

InChI Key: InChIKey=IZDBEJJRNUSRIU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 180871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM180871 (US9133180, 12) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(c2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N5O2/c1-24(2)13-33(12-11-31-24)15-5-3-14(4-6-15)21-20(22(29)34)32-23(35-21)17-7-8-18(25(26,27)28)19-16(17)9-10-30-19/h3-10,30-31H,11-13H2,1-2H3,(H2,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM180871 (US9133180, 12) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(c2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N5O2/c1-24(2)13-33(12-11-31-24)15-5-3-14(4-6-15)21-20(22(29)34)32-23(35-21)17-7-8-18(25(26,27)28)19-16(17)9-10-30-19/h3-10,30-31H,11-13H2,1-2H3,(H2,29,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM180871 (US9133180, 12) Show SMILES CC1(C)CN(CCN1)c1ccc(cc1)-c1oc(nc1C(N)=O)-c1ccc(c2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C25H24F3N5O2/c1-24(2)13-33(12-11-31-24)15-5-3-14(4-6-15)21-20(22(29)34)32-23(35-21)17-7-8-18(25(26,27)28)19-16(17)9-10-30-19/h3-10,30-31H,11-13H2,1-2H3,(H2,29,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	25
SAREUM LIMITED US Patent					Assay Description Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...				US Patent US9133180 (2015) BindingDB Entry DOI: 10.7270/Q2P55M9X
					More data for this Ligand-Target Pair