BDBM181032 US9676721, 75 2-cyano-1-[(4-{[4-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-3-(pyridin-4-yl)guanidine

SMILES: O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)N1CCOCC1

InChI Key: InChIKey=JLYVBAVPQGOGBN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181032   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181032 (US9676721, 75 2-cyano-1-[(4-{[4-(morpholin-4-yl)be...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C24H24N6O3S/c25-18-28-24(29-20-9-11-26-12-10-20)27-17-19-1-5-22(6-2-19)34(31,32)23-7-3-21(4-8-23)30-13-15-33-16-14-30/h1-12H,13-17H2,(H2,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair