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SMILES: Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1

InChI Key: InChIKey=KASJXJFEJCMFLM-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 181034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor [538-972]


(Homo sapiens (Human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/a7.530



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>3.30E+3n/an/an/an/an/a27



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM181034
PNG
(US9133183, Example 91)
Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1
Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>5.00E+3n/an/an/an/an/a27



Deciphera Pharmaceuticals, LLC

US Patent


Assay Description
These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...


US Patent US9133183 (2015)


BindingDB Entry DOI: 10.7270/Q2DN43TD
More data for this
Ligand-Target Pair