BDBM181058 (E)-N'-(4-Methoxybenzylidene)-4-(2-oxo-2H-chromen-3-yl)thiazole-2-carbohydrazide (7a)

SMILES: COc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)cc1

InChI Key: InChIKey=IURYNOMASDNYPR-SSDVNMTOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Probable maltase-glucoamylase 2 (Homo sapiens)	BDBM181058 ((E)-N'-(4-Methoxybenzylidene)-4-(2-oxo-2H-chro...) Show SMILES COc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)cc1 Show InChI InChI=1S/C21H15N3O4S/c1-27-15-8-6-13(7-9-15)11-22-24-19(25)20-23-17(12-29-20)16-10-14-4-2-3-5-18(14)28-21(16)26/h2-12H,1H3,(H,24,25)/b22-11+	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Babasaheb Bhimrao Ambedkar University (A Central University) Curated by ChEMBL					Assay Description Inhibition of alpha-glucosidase (unknown origin) using p-nitro phenyl glucopyranoside as substrate preincubated for 10 mins followed by substrate add...				Eur J Med Chem 176: 343-377 (2019) Article DOI: 10.1016/j.ejmech.2019.04.025
					More data for this Ligand-Target Pair
Alpha-glucosidase MAL12 (Saccharomyces cerevisiae)	BDBM181058 ((E)-N'-(4-Methoxybenzylidene)-4-(2-oxo-2H-chro...) Show SMILES COc1ccc(\C=N\NC(=O)c2nc(cs2)-c2cc3ccccc3oc2=O)cc1 Show InChI InChI=1S/C21H15N3O4S/c1-27-15-8-6-13(7-9-15)11-22-24-19(25)20-23-17(12-29-20)16-10-14-4-2-3-5-18(14)28-21(16)26/h2-12H,1H3,(H,24,25)/b22-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.17E+4	n/a	n/a	n/a	n/a	6.8	n/a
Jishou University					Assay Description The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...				Bioorg Chem 65: 167-74 (2016) Article DOI: 10.1016/j.bioorg.2016.03.001 BindingDB Entry DOI: 10.7270/Q2445K8R
					More data for this Ligand-Target Pair