BDBM181096 N-(4-fluorobenzylidene)-2-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)acetohydrazide (12b)

SMILES: Cc1nn(-c2ccccc2)c2nc(C)cc(OCC(=O)N\N=C\c3ccc(F)cc3)c12

InChI Key: InChIKey=RGOKSDDGCXEJFD-DHRITJCHSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM181096 (N-(4-fluorobenzylidene)-2-(3,6-dimethyl-1-phenyl-1...) Show SMILES Cc1nn(-c2ccccc2)c2nc(C)cc(OCC(=O)N\N=C\c3ccc(F)cc3)c12 Show InChI InChI=1S/C23H20FN5O2/c1-15-12-20(31-14-21(30)27-25-13-17-8-10-18(24)11-9-17)22-16(2)28-29(23(22)26-15)19-6-4-3-5-7-19/h3-13H,14H2,1-2H3,(H,27,30)/b25-13+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Beni-Suef University					Assay Description Kinase activity was determined using Kinase-Glo Plus luminescence kinase assay kit according to the manufacturer instructions. The assays depend on t...				Bioorg Chem 66: 88-96 (2016) Article DOI: 10.1016/j.bioorg.2016.03.011 BindingDB Entry DOI: 10.7270/Q2VQ31GF
					More data for this Ligand-Target Pair