BDBM181435 US9139577, 2.044::US9708274, 2.044

SMILES: C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F

InChI Key: InChIKey=SZJIQTPRGDKBTM-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181435 (US9139577, 2.044 | US9708274, 2.044) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C25H27F4N5O3S/c1-14-7-17(34-38(36)11-24(3,4)12-38)9-19-21(14)22(32-13-31-19)33-18-6-5-16(26)8-20(18)37-15(2)23(35)30-10-25(27,28)29/h5-9,13,15H,10-12H2,1-4H3,(H,30,35)(H,31,32,33)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
EVOTEC INTERNATIONAL GMBH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9708274 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JJG
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM181435 (US9139577, 2.044 | US9708274, 2.044) Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CC(C)(C)C1)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C25H27F4N5O3S/c1-14-7-17(34-38(36)11-24(3,4)12-38)9-19-21(14)22(32-13-31-19)33-18-6-5-16(26)8-20(18)37-15(2)23(35)30-10-25(27,28)29/h5-9,13,15H,10-12H2,1-4H3,(H,30,35)(H,31,32,33)/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...				US Patent US9139577 (2015) BindingDB Entry DOI: 10.7270/Q2K64GT1
					More data for this Ligand-Target Pair