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SMILES: CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12

InChI Key: InChIKey=BHMXFSJSWADVLS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM181678 (US9669035, B-23) Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12 Show InChI InChI=1S/C23H28N6O/c1-5-6-9-30-19-11-18(13-24-14-19)23-28-27-22-16(4)26-20-8-7-17(12-25-15(2)3)10-21(20)29(22)23/h7-8,10-11,13-15,25H,5-6,9,12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.8	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...				US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM181678 (US9669035, B-23) Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12 Show InChI InChI=1S/C23H28N6O/c1-5-6-9-30-19-11-18(13-24-14-19)23-28-27-22-16(4)26-20-8-7-17(12-25-15(2)3)10-21(20)29(22)23/h7-8,10-11,13-15,25H,5-6,9,12H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	7.8	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...				US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H
					More data for this Ligand-Target Pair