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SMILES: CNC(c1nc2cc(ccc2[nH]1)C#N)(c1c(C)cc(C)cc1OC)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181732   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM181732 (US9676728, 5 b (±)-2-(2,2,2-Trifluoro-1-(2-methoxy...) Show SMILES CNC(c1nc2cc(ccc2[nH]1)C#N)(c1c(C)cc(C)cc1OC)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9676728 (2017) BindingDB Entry DOI: 10.7270/Q2QN64W8
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM181732 (US9676728, 5 b (±)-2-(2,2,2-Trifluoro-1-(2-methoxy...) Show SMILES CNC(c1nc2cc(ccc2[nH]1)C#N)(c1c(C)cc(C)cc1OC)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9676728 (2017) BindingDB Entry DOI: 10.7270/Q2QN64W8
					More data for this Ligand-Target Pair