BDBM181742 US9676728, 6-E (±)-2-(1-(3-Bromo-6-methoxy-2,4-dimethylphenyl)-2,2,2-trifluoro-1-(methylamino)ethyl)-1H-benzo[d]imidazole-5-carbonitrile

SMILES: CNC(c1nc2cc(ccc2[nH]1)C#N)(c1c(C)c(Br)c(C)cc1OC)C(F)(F)F

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181742   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM181742 (US9676728, 6-E (±)-2-(1-(3-Bromo-6-methoxy-2,4-dim...) Show SMILES CNC(c1nc2cc(ccc2[nH]1)C#N)(c1c(C)c(Br)c(C)cc1OC)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...				US Patent US9676728 (2017) BindingDB Entry DOI: 10.7270/Q2QN64W8
					More data for this Ligand-Target Pair