BDBM182050 US9145391, 1-18

SMILES: Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCC(CC1)C(O)=O

InChI Key: InChIKey=OIDGOQKUFDDNOT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182050   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182050 (US9145391, 1-18) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCC(CC1)C(O)=O |(-1.28,-9.05,;-2.37,-7.96,;-3.85,-8.36,;-4.94,-7.27,;-6.43,-7.67,;-7.52,-6.58,;-7.12,-5.09,;-8.21,-4,;-9.7,-4.4,;-10.1,-5.89,;-9.01,-6.98,;-7.81,-2.52,;-8.9,-1.43,;-7.04,-1.18,;-6.48,-3.29,;-4.54,-5.78,;-3.06,-5.38,;-1.97,-6.47,;-2.66,-3.9,;-1.17,-3.5,;-.77,-2.01,;-1.86,-.92,;-3.35,-1.32,;-3.75,-2.81,;-1.46,.57,;-3.16,1.7,;-.69,1.9,;.85,1.9,;1.67,.57,;.85,-.77,;-.69,-.77,;3.21,.57,;3.98,-.77,;3.98,1.9,)| Show InChI InChI=1S/C24H23F3N4O3/c1-14-10-18(30-21(11-14)31-20-12-17(6-9-28-20)24(25,26)27)16-2-3-19(29-13-16)23(34)7-4-15(5-8-23)22(32)33/h2-3,6,9-13,15,34H,4-5,7-8H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
					More data for this Ligand-Target Pair