BDBM182061 US9145391, 1-29

SMILES: Cc1cc(Nc2cc(OC(C)(C)C)ccn2)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O

InChI Key: InChIKey=ZQCOZLUOTAEMBP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182061 (US9145391, 1-29) Show SMILES Cc1cc(Nc2cc(OC(C)(C)C)ccn2)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(.33,-9.24,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-7.67,-4.62,;-6.34,-3.85,;-5.94,-2.36,;-5.11,-4.79,;-7.56,-2.91,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)| Show InChI InChI=1S/C29H36N4O4/c1-18-14-23(32-26(15-18)33-25-16-22(12-13-30-25)37-28(2,3)4)20-8-11-24(31-17-20)29(5,36)21-9-6-19(7-10-21)27(34)35/h8,11-17,19,21,36H,6-7,9-10H2,1-5H3,(H,34,35)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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