BDBM182068 US9145391, 1-36

SMILES: CC(=O)C(C)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1

InChI Key: InChIKey=WMTUFETXGSBENV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182068 (US9145391, 1-36) Show SMILES CC(=O)C(C)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |(2.04,-3.23,;1.27,-1.9,;2.04,-.56,;-.27,-1.9,;-1.81,-1.9,;-.27,-.36,;1.06,.41,;1.06,1.95,;-.27,2.72,;-1.6,1.95,;-1.6,.41,;-.27,4.26,;1.06,5.03,;-1.6,5.03,;-.27,-3.44,;1.06,-4.21,;1.06,-5.75,;-.27,-6.52,;-1.6,-5.75,;-1.6,-4.21,;-.27,-8.06,;1.06,-8.83,;1.06,-10.37,;2.4,-11.14,;-.27,-11.14,;-1.6,-10.37,;-2.94,-11.14,;-4.27,-10.37,;-4.27,-8.83,;-5.6,-8.06,;-6.94,-8.83,;-6.94,-10.37,;-5.6,-11.14,;-5.6,-6.52,;-6.94,-5.75,;-4.23,-5.71,;-1.6,-8.83,)| Show InChI InChI=1S/C28H30F2N4O3/c1-16-12-22(33-25(13-16)34-24-14-19(26(29)30)10-11-31-24)20-6-9-23(32-15-20)28(3,17(2)35)21-7-4-18(5-8-21)27(36)37/h6,9-15,18,21,26H,4-5,7-8H2,1-3H3,(H,36,37)(H,31,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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