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SMILES: CCNCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1

InChI Key: InChIKey=ZHOGIIGEXYVVFK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 182858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM182858 (US9669035, B-32) Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1 Show InChI InChI=1S/C22H24N6O/c1-3-23-10-16-6-7-19-20(8-16)28-21(14(2)25-19)26-27-22(28)17-9-18(12-24-11-17)29-13-15-4-5-15/h6-9,11-12,15,23H,3-5,10,13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.8	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...				US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM182858 (US9669035, B-32) Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1 Show InChI InChI=1S/C22H24N6O/c1-3-23-10-16-6-7-19-20(8-16)28-21(14(2)25-19)26-27-22(28)17-9-18(12-24-11-17)29-13-15-4-5-15/h6-9,11-12,15,23H,3-5,10,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	7.8	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...				US Patent US9669035 (2017) BindingDB Entry DOI: 10.7270/Q2Z60M6H
					More data for this Ligand-Target Pair