BDBM183544 US9145354, 178

SMILES: CC[C@H](N[C@H](C)CO)c1ccc(Cl)c(C(=O)c2ccc(N)nc2)c1F

InChI Key: InChIKey=SRGBGHPTXUIAOR-YGRLFVJLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HCV NS3-NS4A Serine Proteinase (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM183544 (US9145354, 178) Show SMILES CC[C@H](N[C@H](C)CO)c1ccc(Cl)c(C(=O)c2ccc(N)nc2)c1F |r| Show InChI InChI=1S/C18H21ClFN3O2/c1-3-14(23-10(2)9-24)12-5-6-13(19)16(17(12)20)18(25)11-4-7-15(21)22-8-11/h4-8,10,14,23-24H,3,9H2,1-2H3,(H2,21,22)/t10-,14+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	25
ASTEX THERAPEUTICS LIMITED US Patent					Assay Description The HCV NS3 protease functions have been extensively studied and are considered as potential targets for antiviral therapy: see for example the many ...				US Patent US9145354 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MMZ
					More data for this Ligand-Target Pair