BDBM183619 US9145354, 286

SMILES: CC[C@H](NC(=O)C1=CCNC1)c1ccc(Cl)c(C(=O)c2cccnc2)c1F

InChI Key: InChIKey=ASNWWEXMMZBHJU-INIZCTEOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HCV NS3-NS4A Serine Proteinase (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM183619 (US9145354, 286) Show SMILES CC[C@H](NC(=O)C1=CCNC1)c1ccc(Cl)c(C(=O)c2cccnc2)c1F |r,t:6| Show InChI InChI=1S/C20H19ClFN3O2/c1-2-16(25-20(27)13-7-9-24-11-13)14-5-6-15(21)17(18(14)22)19(26)12-4-3-8-23-10-12/h3-8,10,16,24H,2,9,11H2,1H3,(H,25,27)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	25
ASTEX THERAPEUTICS LIMITED US Patent					Assay Description The HCV NS3 protease functions have been extensively studied and are considered as potential targets for antiviral therapy: see for example the many ...				US Patent US9145354 (2015) BindingDB Entry DOI: 10.7270/Q2VH5MMZ
					More data for this Ligand-Target Pair