BDBM18383 Alkyl substituted pyrrole compound, 29e::sodium (3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-4-methyl-5-{[(5-methylpyrazin-2-yl)methyl]carbamoyl}-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate

SMILES: CCn1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c(c(C)c1C(=O)NCc1cnc(C)cn1)-c1ccc(F)cc1

InChI Key: InChIKey=XOXXJOLIUVJJAA-FGZHOGPDSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM18383 (Alkyl substituted pyrrole compound, 29e | sodium (...) Show SMILES CCn1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c(c(C)c1C(=O)NCc1cnc(C)cn1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C27H33FN4O5/c1-4-32-23(10-9-21(33)11-22(34)12-24(35)36)25(18-5-7-19(28)8-6-18)17(3)26(32)27(37)31-15-20-14-29-16(2)13-30-20/h5-8,13-14,21-22,33-34H,4,9-12,15H2,1-3H3,(H,31,37)(H,35,36)/p-1/t21-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	7.2	37
Pfizer					Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...				Bioorg Med Chem 15: 5576-89 (2007) Article DOI: 10.1016/j.bmc.2007.05.031 BindingDB Entry DOI: 10.7270/Q23J3B7G
					More data for this Ligand-Target Pair