BDBM183927 US9150526, 185

SMILES: COc1ccc(cc1-c1cccc(c1)[C@@H](CC(O)=O)c1nnc(C)o1)C(C)C

InChI Key: InChIKey=RANOEZSXOGUFFY-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 183927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin A (CTSA) (Homo sapiens (Human))	BDBM183927 (US9150526, 185) Show SMILES COc1ccc(cc1-c1cccc(c1)[C@@H](CC(O)=O)c1nnc(C)o1)C(C)C Show InChI InChI=1S/C22H24N2O4/c1-13(2)15-8-9-20(27-4)18(11-15)16-6-5-7-17(10-16)19(12-21(25)26)22-24-23-14(3)28-22/h5-11,13,19H,12H2,1-4H3,(H,25,26)/t19-/m1/s1	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	6.0	37
Sanofi US Patent					Assay Description Recombinant human cathepsin A (residues 29-480, with a C-terminal 10-His tag; R&D Systems, #1049-SE) was proteolytically activated with recombinant h...				US Patent US9150526 (2015) BindingDB Entry DOI: 10.7270/Q2QR4VXP
					More data for this Ligand-Target Pair