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SMILES: FC(F)(F)Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12

InChI Key: InChIKey=HUUWZKOEZNZFQR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184227   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ribosomal protein S6 kinase alpha-2


(Homo sapiens (Human))		BDBM184227
PNG
(US9150577, 87)
Show SMILES FC(F)(F)Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12
Show InChI InChI=1S/C22H18F3N5O2/c23-22(24,25)12-30-16-5-2-1-4-15(16)27-21(30)28-19(31)14-7-6-13-10-18-20(32)26-8-3-9-29(18)17(13)11-14/h1-2,4-7,10-11H,3,8-9,12H2,(H,26,32)(H,27,28,31)
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Similars
US Patent
n/an/a 4.80n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...

US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair