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SMILES: COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1

InChI Key: InChIKey=WSEOWNBBPGNYRJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184506   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin receptor [964-1370]


(Homo sapiens (Human))		BDBM184506
PNG
(US9150578, I-135)
Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C36H41N9O3/c1-43-22-27(21-38-43)23-5-7-24(8-6-23)34-32-30(42-44(34)2)12-10-26-20-37-36(41-33(26)32)40-29-11-9-25(19-31(29)48-4)35(46)39-28-13-15-45(16-14-28)17-18-47-3/h5-9,11,19-22,28H,10,12-18H2,1-4H3,(H,39,46)(H,37,40,41)
PDB

UniProtKB/SwissProt

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PC sid
UniChem

Similars
US Patent
n/an/a 0.140n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...

US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair