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SMILES: COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C1CCOCC1

InChI Key: InChIKey=KUXYUFHYERAGDG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184544   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin receptor [964-1370]


(Homo sapiens (Human))		BDBM184544
PNG
(US9150578, I-171)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C36H41N9O2/c1-42-23-27(22-38-42)24-4-6-25(7-5-24)35-33-31(41-43(35)2)10-8-26-21-37-36(40-34(26)33)39-30-11-9-29(20-32(30)46-3)45-16-14-44(15-17-45)28-12-18-47-19-13-28/h4-7,9,11,20-23,28H,8,10,12-19H2,1-3H3,(H,37,39,40)
PDB

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...

US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair