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SMILES: COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CCO)CC1

InChI Key: InChIKey=ZEPVDOIWFVBKOM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184548   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin receptor [964-1370]


(Homo sapiens (Human))		BDBM184548
PNG
(US9150578, I-174)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CCO)CC1
Show InChI InChI=1S/C33H37N9O2/c1-39-21-25(20-35-39)22-4-6-23(7-5-22)32-30-28(38-40(32)2)10-8-24-19-34-33(37-31(24)30)36-27-11-9-26(18-29(27)44-3)42-14-12-41(13-15-42)16-17-43/h4-7,9,11,18-21,43H,8,10,12-17H2,1-3H3,(H,34,36,37)
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PC cid
PC sid
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Similars
US Patent
n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...

US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair