BDBM18520 6-(1-Pyrrolidine)quinolin-2(1H)-one, 4e::6-[(2R,5R)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one

SMILES: C[C@@H]1CC[C@H](CO)N1c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F

InChI Key: InChIKey=RJQYEUKBEQAJBR-MWLCHTKSSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Androgen receptor (Homo sapiens (Human))	BDBM18520 (6-(1-Pyrrolidine)quinolin-2(1H)-one, 4e | 6-[(2R,5...) Show SMILES C[C@@H]1CC[C@H](CO)N1c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F |r| Show InChI InChI=1S/C16H17F3N2O2/c1-9-2-3-11(8-22)21(9)10-4-5-14-12(6-10)13(16(17,18)19)7-15(23)20-14/h4-7,9,11,22H,2-3,8H2,1H3,(H,20,23)/t9-,11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	70	-10.1	n/a	n/a	21	n/a	n/a	7.4	37
Ligand Pharmaceuticals Inc.					Assay Description The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...				J Med Chem 50: 5049-52 (2007) Article DOI: 10.1021/jm070231h BindingDB Entry DOI: 10.7270/Q29Z935Z
					More data for this Ligand-Target Pair