BDBM185438 US9156845, 87

SMILES: Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F

InChI Key: InChIKey=IGWCOHZVLMWAFD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185438   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human))	BDBM185438 (US9156845, 87) Show SMILES Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F Show InChI InChI=1S/C16H14F2N4O/c17-12-3-1-2-10(14(12)18)11-8-19-15-13(11)16(21-9-20-15)22-4-6-23-7-5-22/h1-3,8-9H,4-7H2,(H,19,20,21)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM185438 (US9156845, 87) Show SMILES Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1F Show InChI InChI=1S/C16H14F2N4O/c17-12-3-1-2-10(14(12)18)11-8-19-15-13(11)16(21-9-20-15)22-4-6-23-7-5-22/h1-3,8-9H,4-7H2,(H,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair