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SMILES: COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12

InChI Key: InChIKey=CNKMORSUWBKGDA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM185509 (US9156845, 163) Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12 Show InChI InChI=1S/C18H18F2N4O/c1-25-15-3-2-12(20)8-13(15)14-9-21-17-16(14)18(23-10-22-17)24-6-4-11(19)5-7-24/h2-3,8-11H,4-7H2,1H3,(H,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM185509 (US9156845, 163) Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12 Show InChI InChI=1S/C18H18F2N4O/c1-25-15-3-2-12(20)8-13(15)14-9-21-17-16(14)18(23-10-22-17)24-6-4-11(19)5-7-24/h2-3,8-11H,4-7H2,1H3,(H,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...				US Patent US9156845 (2015) BindingDB Entry DOI: 10.7270/Q2DB80MW
					More data for this Ligand-Target Pair