BDBM18556 7-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one::alkylamino-2-quinolinone, 10b
SMILES: CCN(CC)c1ccc2c(cc(=O)[nH]c2c1)C(F)(F)F
InChI Key: InChIKey=UILFNGMMUOMMAP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen Receptor (Homo sapiens (Human)) | BDBM18556 (7-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroqu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 463 | -8.98 | 591 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Ligand Pharmaceuticals Inc. | Assay Description The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece... | Bioorg Med Chem Lett 17: 1523-6 (2007) Article DOI: 10.1016/j.bmcl.2007.01.007 BindingDB Entry DOI: 10.7270/Q22J6950 | |||||||||||
More data for this Ligand-Target Pair |