BDBM186106 US9163012, 24, Isomer 1::US9163012, 24, Isomer 2

SMILES: OC12CC3CC(C1)C(OC(=O)N1CCC(C1)c1ncc(Cl)cn1)C(C3)C2

InChI Key: InChIKey=VBFMSLCCLACWLX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM186106 (US9163012, 24, Isomer 1 | US9163012, 24, Isomer 2) Show SMILES OC12CC3CC(C1)C(OC(=O)N1CCC(C1)c1ncc(Cl)cn1)C(C3)C2 |TLB:4:5:25:2.3.24,4:3:25:5.7.6,THB:7:5:2:25.23.24,7:23:2:5.4.6,8:7:25:2.3.24,(-8.16,-1.97,;-6.82,-1.2,;-7.66,-3.1,;-6.26,-2.46,;-5.06,-3.13,;-4.16,-1.2,;-5.49,-1.97,;-4.16,.34,;-2.83,1.11,;-1.5,.34,;-1.5,-1.2,;-.16,1.11,;-.16,2.65,;1.3,3.13,;2.21,1.88,;1.3,.63,;3.7,1.48,;4.09,-.01,;5.58,-.4,;6.67,.68,;8.16,.29,;6.27,2.17,;4.78,2.57,;-5.49,1.11,;-6.25,-.06,;-6.82,.34,)| Show InChI InChI=1S/C19H24ClN3O3/c20-15-8-21-17(22-9-15)12-1-2-23(10-12)18(24)26-16-13-3-11-4-14(16)7-19(25,5-11)6-13/h8-9,11-14,16,25H,1-7,10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	25
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of microsomal preparations of 11.beta.-HSDl by compounds of the present invention, as described essentially previously (K. Solly, SS Mundt...				US Patent US9163012 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W45
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM186106 (US9163012, 24, Isomer 1 | US9163012, 24, Isomer 2) Show SMILES OC12CC3CC(C1)C(OC(=O)N1CCC(C1)c1ncc(Cl)cn1)C(C3)C2 |TLB:4:5:25:2.3.24,4:3:25:5.7.6,THB:7:5:2:25.23.24,7:23:2:5.4.6,8:7:25:2.3.24,(-8.16,-1.97,;-6.82,-1.2,;-7.66,-3.1,;-6.26,-2.46,;-5.06,-3.13,;-4.16,-1.2,;-5.49,-1.97,;-4.16,.34,;-2.83,1.11,;-1.5,.34,;-1.5,-1.2,;-.16,1.11,;-.16,2.65,;1.3,3.13,;2.21,1.88,;1.3,.63,;3.7,1.48,;4.09,-.01,;5.58,-.4,;6.67,.68,;8.16,.29,;6.27,2.17,;4.78,2.57,;-5.49,1.11,;-6.25,-.06,;-6.82,.34,)| Show InChI InChI=1S/C19H24ClN3O3/c20-15-8-21-17(22-9-15)12-1-2-23(10-12)18(24)26-16-13-3-11-4-14(16)7-19(25,5-11)6-13/h8-9,11-14,16,25H,1-7,10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.29	n/a	n/a	n/a	n/a	n/a	25
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of microsomal preparations of 11.beta.-HSDl by compounds of the present invention, as described essentially previously (K. Solly, SS Mundt...				US Patent US9163012 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W45
					More data for this Ligand-Target Pair