BDBM186136 US9163012, 53

SMILES: Cn1ccc(cc1=O)-c1csc(n1)[C@H]1CCCN1C(=O)OC1C2CC3CC(C2)CC1C3

InChI Key: InChIKey=VOOUNAQQLKAMAA-FOQJIBBJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM186136 (US9163012, 53) Show SMILES Cn1ccc(cc1=O)-c1csc(n1)[C@H]1CCCN1C(=O)OC1C2CC3CC(C2)CC1C3 |r,wD:13.14,TLB:20:21:23:25.26.27,THB:21:29:25:23.22.27,21:22:25:29.28.30,28:29:23:25.26.27,28:26:23:29.21.30,(3.94,-6.2,;3.54,-4.71,;2.06,-4.31,;1.66,-2.83,;2.75,-1.74,;4.23,-2.14,;4.63,-3.62,;6.12,-4.02,;2.35,-.25,;.88,.23,;.88,1.77,;2.35,2.24,;3.25,1,;3.12,3.57,;4.58,4.05,;4.58,5.59,;3.12,6.07,;2.21,4.82,;.72,4.42,;.32,2.94,;-.36,5.51,;-1.85,5.11,;-2.94,6.2,;-4.42,5.8,;-4.82,4.32,;-6.12,2.7,;-4.6,2.96,;-3.97,5.27,;-3.61,2,;-2.25,3.63,;-3.73,3.23,)| Show InChI InChI=1S/C24H29N3O3S/c1-26-6-4-16(12-21(26)28)19-13-31-23(25-19)20-3-2-5-27(20)24(29)30-22-17-8-14-7-15(10-17)11-18(22)9-14/h4,6,12-15,17-18,20,22H,2-3,5,7-11H2,1H3/t14?,15?,17?,18?,20-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	25
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of microsomal preparations of 11.beta.-HSDl by compounds of the present invention, as described essentially previously (K. Solly, SS Mundt...				US Patent US9163012 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W45
					More data for this Ligand-Target Pair