BDBM186348 US9163021, 5

SMILES: CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncc(F)c12

InChI Key: InChIKey=HLUAVPHBLJJSSL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186348   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186348 (US9163021, 5) Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncc(F)c12 Show InChI InChI=1S/C26H22F4N4O3/c1-25(2,14-35)34-13-20(19-11-32-12-21(27)23(19)34)24(37)16-8-18(10-31-9-16)33-22(36)7-15-4-3-5-17(6-15)26(28,29)30/h3-6,8-13,35H,7,14H2,1-2H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.41	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair