BDBM186375 US9163021, 32

SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cncc(F)c12

InChI Key: InChIKey=GWHBTXYPXPOISG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186375 (US9163021, 32) Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cncc(F)c12 Show InChI InChI=1S/C23H20F4N6O2/c1-12(2)32-10-17(16-8-29-9-18(24)21(16)32)22(35)14-5-15(7-28-6-14)30-20(34)11-33-13(3)4-19(31-33)23(25,26)27/h4-10,12H,11H2,1-3H3,(H,30,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair