BDBM186445 US9163021, 103

SMILES: CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnccc12

InChI Key: InChIKey=NXCHDYUPIAJKRN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186445 (US9163021, 103) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnccc12 Show InChI InChI=1S/C24H21ClN4O2/c1-15(2)29-14-20(19-13-26-9-8-21(19)29)24(31)17-7-10-27-22(12-17)28-23(30)11-16-3-5-18(25)6-4-16/h3-10,12-15H,11H2,1-2H3,(H,27,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair