BDBM186505 US9163021, 168

SMILES: CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(OC(F)(F)F)cc3)c2)c2cnccc12

InChI Key: InChIKey=XABXALJOCSIXPG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186505   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186505 (US9163021, 168) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(OC(F)(F)F)cc3)c2)c2cnccc12 Show InChI InChI=1S/C25H21F3N4O3/c1-15(2)32-14-20(19-13-29-9-8-21(19)32)24(34)17-7-10-30-22(12-17)31-23(33)11-16-3-5-18(6-4-16)35-25(26,27)28/h3-10,12-15H,11H2,1-2H3,(H,30,31,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair