BDBM186518 US9163021, 183

SMILES: CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cnccc12

InChI Key: InChIKey=VTVAJMDDUQGXDE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186518 (US9163021, 183) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cnccc12 Show InChI InChI=1S/C25H21N5O2/c1-16(2)30-15-21(20-14-27-9-8-22(20)30)25(32)19-7-10-28-23(12-19)29-24(31)11-17-3-5-18(13-26)6-4-17/h3-10,12,14-16H,11H2,1-2H3,(H,28,29,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair