BDBM186541 US9163021, 209::US9163021, 222::US9163021, 224
SMILES: CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncc(F)c12
InChI Key: InChIKey=GAGVFTJQVOCNEX-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM186541 (US9163021, 209 | US9163021, 222 | US9163021, 224) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 264 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou... | US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM186541 (US9163021, 209 | US9163021, 222 | US9163021, 224) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou... | US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM186541 (US9163021, 209 | US9163021, 222 | US9163021, 224) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 16.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou... | US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C | |||||||||||
More data for this Ligand-Target Pair |