BDBM186566 US9163021, 234

SMILES: CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cn3ccc(n3)C3CC3)ccn2)c2cnccc12

InChI Key: InChIKey=VJBAQEIDYQIFER-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186566   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186566 (US9163021, 234) Show SMILES CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cn3ccc(n3)C3CC3)ccn2)c2cnccc12 Show InChI InChI=1S/C25H26N6O3/c1-25(2,15-32)31-13-19(18-12-26-8-6-22(18)31)24(34)21-11-17(5-9-27-21)28-23(33)14-30-10-7-20(29-30)16-3-4-16/h5-13,16,32H,3-4,14-15H2,1-2H3,(H,27,28,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
					More data for this Ligand-Target Pair