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BDBM186570 US9163040, 2

SMILES: OC(=O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)CCP(O)(O)=O

InChI Key: InChIKey=TWKJROJSAYIJLA-OAHLLOKOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186570   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM186570
PNG
(US9163040, 2)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)CCP(O)(O)=O
Show InChI InChI=1S/C19H20ClFNO6P/c20-14-5-6-17(21)16(10-14)13-3-1-12(2-4-13)9-15(11-19(24)25)22-18(23)7-8-29(26,27)28/h1-6,10,15H,7-9,11H2,(H,22,23)(H,24,25)(H2,26,27,28)/t15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 pM) is pre-incubated wi...


Citation and Details
More data for this
Ligand-Target Pair