BDBM187049 US9169209, Table 3, Compound 82

SMILES: COc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1

InChI Key: InChIKey=RTKGWBZRPFFWOI-RUDMXATFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM187049 (US9169209, Table 3, Compound 82) Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1 Show InChI InChI=1S/C21H17FN2O4S/c1-28-18-11-16(22)12-20(13-18)29(26,27)19-7-5-17(6-8-19)24-21(25)9-4-15-3-2-10-23-14-15/h2-14H,1H3,(H,24,25)/b9-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair