BDBM187244 US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine

SMILES: CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F

InChI Key: InChIKey=YGHYXNJYKCDPAN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 187244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM187244 (US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...) Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM187244 (US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...) Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair
HDAC4 (aa 2-1084) (Homo sapiens (Human))	BDBM187244 (US9670193, 17 N-methyl-N-((2-methylpyridin-4-yl)me...) Show SMILES CN(Cc1ccnc(C)c1)c1ncc(cn1)-c1noc(n1)C(F)(F)F Show InChI InChI=1S/C15H13F3N6O/c1-9-5-10(3-4-19-9)8-24(2)14-20-6-11(7-21-14)12-22-13(25-23-12)15(16,17)18/h3-7H,8H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	8.0	25
Novartis AG US Patent					Assay Description Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair