BindingDB logo
myBDB logout

null

SMILES: COc1nc(-c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)c(OCc2ccccc2)c(=O)[nH]1

InChI Key: InChIKey=VEIFDWKVGYRJBA-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187309   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))		BDBM187309
PNG
(US9169240, 48)
Show SMILES COc1nc(-c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)c(OCc2ccccc2)c(=O)[nH]1
Show InChI InChI=1S/C28H18FN5O5S/c1-37-28-31-21(23(24(36)32-28)38-14-15-5-3-2-4-6-15)25-33-34-26(39-25)22(35)27-30-19-12-9-17(13-20(19)40-27)16-7-10-18(29)11-8-16/h2-13H,14H2,1H3,(H,31,32,36)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 122n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...

US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair