BDBM187640 US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyridin-2-amine

SMILES: FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1

InChI Key: InChIKey=OQGVSLTWHDCVQM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 187640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM187640 (US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...) Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1 Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM187640 (US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...) Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1 Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair
HDAC4 (aa 2-1084) (Homo sapiens (Human))	BDBM187640 (US9670193, 33 N-benzyl-3-chloro-5-(5-(trifluoromet...) Show SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)c(Cl)c1 Show InChI InChI=1S/C15H10ClF3N4O/c16-11-6-10(12-22-14(24-23-12)15(17,18)19)8-21-13(11)20-7-9-4-2-1-3-5-9/h1-6,8H,7H2,(H,20,21)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	8.0	25
Novartis AG US Patent					Assay Description Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...				US Patent US9670193 (2017) BindingDB Entry DOI: 10.7270/Q2SF2TCV
					More data for this Ligand-Target Pair