BDBM187974 US9169252, 517

SMILES: CC(C)(F)[C@H](F)CNC(=O)c1cnc(cc1Nc1cccc(O)c1)-n1ccc2cc(cnc12)C#N

InChI Key: InChIKey=UOYZSRSFFJIIKF-OAQYLSRUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187974   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187974 (US9169252, 517) Show SMILES CC(C)(F)[C@H](F)CNC(=O)c1cnc(cc1Nc1cccc(O)c1)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C25H22F2N6O2/c1-25(2,27)21(26)14-31-24(35)19-13-29-22(10-20(19)32-17-4-3-5-18(34)9-17)33-7-6-16-8-15(11-28)12-30-23(16)33/h3-10,12-13,21,34H,14H2,1-2H3,(H,29,32)(H,31,35)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
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