BDBM188337 US9670194, Ex. 19 (R)-2-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)propyl)-5-chloro-3-cyclopropylquinazolin-4(3H)-one

SMILES: CC[C@@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1

InChI Key: InChIKey=XHQKEWGONWROCR-CYBMUJFWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188337   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110δ/p85α (Homo sapiens (Human))	BDBM188337 (US9670194, Ex. 19 (R)-2-(1-((6-amino-5-(3-methyl-1...) Show SMILES CC[C@@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair